6RLY

Human MMP12 (catalytic domain) in complex with AP316

Summary for 6RLY

Entry DOI	10.2210/pdb6rly/pdb
Descriptor	Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (6 entities in total)
Functional Keywords	mmp12, inhibitors, catalytic domain, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	18290.18
Authors	Calderone, V.,Fragai, M.,Luchinat, C. (deposition date: 2019-05-03, release date: 2020-03-11, Last modification date: 2024-01-24)
Primary citation	Tsoukalidou, S.,Kakou, M.,Mavridis, I.,Koumantou, D.,Calderone, V.,Fragai, M.,Stratikos, E.,Papakyriakou, A.,Vourloumis, D. Exploration of zinc-binding groups for the design of inhibitors for the oxytocinase subfamily of M1 aminopeptidases. Bioorg.Med.Chem., 27:115177-115177, 2019 Cited by PubMed: 31711716 DOI: 10.1016/j.bmc.2019.115177 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation