6RLO

Crystal structure of AT1412dm Fab fragment in complex with CD9 large extracellular loop

Summary for 6RLO

• Entry DOI: 10.2210/pdb6rlo/pdb
• Descriptor: AT1412dm Fab Fragment (Heavy Chain), AT1412dm Fab Fragment (Light Chain), CD9 antigen, ... (7 entities in total)
• Functional Keywords: antibody, fab, cd9-binding, affinity-improvement, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 12
• Total formula weight: 233990.53

Authors

Neviani, V.,Pearce, N.M.,Pos, W.,Schotte, R.,Spits, H.,Gros, P. (deposition date: 2019-05-02, release date: 2021-05-12, Last modification date: 2024-01-24)

• Primary citation: Neviani, V.,Pos, W.,Schotte, R.,Wagner, K.,Go, D.M.,Fatmawati, C.,Kedde, M.,Claassen, Y.B.,Kroon-Batenburg, L.,Lutz, M.,Verdegaal, E.M.E.,van der Burg, S.H.,Spits, H.,Gros, P.; Structural basis of a homo-dimerization site in tetraspanin CD9 targeted by a melanoma patient-derived antibody; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)