6RLO

Crystal structure of AT1412dm Fab fragment in complex with CD9 large extracellular loop

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, C, E, G)	AT1412dm Fab Fragment (Heavy Chain)	polymer	223	23827.7	4		Homo sapiens
2	B, E, H, K (B, D, F, H)	AT1412dm Fab Fragment (Light Chain)	polymer	220	24261.8	4		Homo sapiens
3	C, F, I, L (I, J, K, L)	CD9 antigen	polymer	90	10260.6	4	UniProt (P21926) Pfam (PF00335)	Homo sapiens (Human)	5H9 antigen,Cell growth-inhibiting gene 2 protein,Leukocyte antigen MIC3,Motility-related protein,MRP-1,Tetraspanin-29,Tspan-29,p24
4	BA, DA, EA, M, N... (F, G, H, A, B...)	CHLORIDE ION	non-polymer		35.5	11	Chemie (CL)
5	P (B)	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
6	AA, CA, Q, U, V... (D, F, B, C)	SODIUM ION	non-polymer		23.0	7	Chemie (NA)
7	FA, GA, HA, IA, JA... (A, B, I, C, D...)	water	water		18.0	212	Chemie (HOH)

Sequence modifications

I, J, K, L: 114 - 191 (UniProt: P21926)

PDB	External Database	Details
Met 111	-	initiating methionine
Gly 112	-	expression tag
Ser 113	-	expression tag
Ala 192	-	expression tag
Ala 193	-	expression tag
Ala 194	-	expression tag
His 195	-	expression tag
His 196	-	expression tag
His 197	-	expression tag
His 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	233400.5
Non-Polymers*	Number of molecules	19
	Total formula weight	590.0
All*	Total formula weight	233990.5

*Water molecules are not included.