6RKQ

Crystal Structure of TGT in complex with N2-methyl-8-(prop-1-yn-1-yl)-3H,7H,8H-imidazo[4,5-g]quinazoline-2,6-diamine

6RKQ の概要

• エントリーDOI: 10.2210/pdb6rkq/pdb
• 分子名称: Queuine tRNA-ribosyltransferase, ZINC ION, (8~{R})-~{N}2-methyl-8-prop-1-ynyl-7,8-dihydro-3~{H}-imidazo[4,5-g]quinazoline-2,6-diamine, ... (6 entities in total)
• 機能のキーワード: tgt, trna, guanine exchange enzyme, protein interface, transferase, transglycosylase
• 由来する生物種: Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42253.41

構造登録者

Hassaan, E.,Heine, A.,Klebe, G. (登録日: 2019-04-30, 公開日: 2020-06-03, 最終更新日: 2024-01-24)

• 主引用文献: Hassaan, E.,Hohn, C.,Ehrmann, F.R.,Goetzke, F.W.,Movsisyan, L.,Hufner-Wulsdorf, T.,Sebastiani, M.,Hartsch, A.,Reuter, K.,Diederich, F.,Klebe, G.; Fragment Screening Hit Draws Attention to a Novel Transient Pocket Adjacent to the Recognition Site of the tRNA-Modifying Enzyme TGT.; J.Med.Chem., 63:6802-6820, 2020; PubMed: 32515955; DOI: 10.1021/acs.jmedchem.0c00115

実験手法

X-RAY DIFFRACTION (1.665 Å)