6RKP

Crystal structure of human monoamine oxidase B in complex with styrylpiperidine analogue 84

6RKP の概要

• エントリーDOI: 10.2210/pdb6rkp/pdb
• 分子名称: Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, 1-[(~{E})-prop-1-enyl]-4-[(~{E})-2-[4-(trifluoromethyl)phenyl]ethenyl]piperidine, ... (6 entities in total)
• 機能のキーワード: monoamine oxidase, drug target, neurodegeneration, flavin, isomer, mitochondrial membrane, flavoprotein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 120694.54

構造登録者

Iacovino, L.G.,Knez, D.,Colettis, N.,Sova, M.,Pislar, A.,Higgs, J.,Kamecki, F.,Mangialavori, I.,Dolsak, A.,Zakelj, S.,Trontelj, J.,Kos, J.,Marder, N.M.,Gobec, S.,Binda, C. (登録日: 2019-04-30, 公開日: 2020-01-29, 最終更新日: 2024-01-24)

• 主引用文献: Knez, D.,Colettis, N.,Iacovino, L.G.,Sova, M.,Pislar, A.,Konc, J.,Lesnik, S.,Higgs, J.,Kamecki, F.,Mangialavori, I.,Dolsak, A.,Zakelj, S.,Trontelj, J.,Kos, J.,Binda, C.,Marder, M.,Gobec, S.; Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B.; J.Med.Chem., 63:1361-1387, 2020; PubMed: 31917923; DOI: 10.1021/acs.jmedchem.9b01886

実験手法

X-RAY DIFFRACTION (1.7 Å)