6RIO

Imidazole Polyamide-DNA complex NMR structure (5'-CGATGTACATCG-3')

Summary for 6RIO

• Entry DOI: 10.2210/pdb6rio/pdb
• NMR Information: BMRB: 34397
• Descriptor: DNA (5'-(*(DC5)P*GP*AP*TP*GP*TP*AP*CP*AP*TP*CP*(DG3))-3'), 3-[3-[[4-[[4-[[4-[[4-[[(2~{R})-2-azaniumyl-4-[[1-methyl-4-[[1-methyl-4-[[1-methyl-4-[(1-methylimidazol-2-yl)carbonylamino]pyrrol-2-yl]carbonylamino]pyrrol-2-yl]carbonylamino]pyrrol-2-yl]carbonylamino]butanoyl]amino]-1-methyl-imidazol-2-yl]carbonylamino]-1-methyl-pyrrol-2-yl]carbonylamino]-1-methyl-pyrrol-2-yl]carbonylamino]-1-methyl-pyrrol-2-yl]carbonylamino]propanoylamino]propyl-dimethyl-azanium (2 entities in total)
• Functional Keywords: polyamide, dna, minor groove binder
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 8404.20

Authors

Padroni, G.,Withers, J.M.,Taladriz-Sender, A.,Reichenbach, L.F.,Parkinson, J.A.,Burley, G.A. (deposition date: 2019-04-24, release date: 2019-06-12, Last modification date: 2020-03-04)

• Primary citation: Padroni, G.,Withers, J.M.,Taladriz-Sender, A.,Reichenbach, L.F.,Parkinson, J.A.,Burley, G.A.; Sequence-Selective Minor Groove Recognition of a DNA Duplex Containing Synthetic Genetic Components.; J.Am.Chem.Soc., 141:9555-9563, 2019; PubMed: 31117639; DOI: 10.1021/jacs.8b12444

Experimental method

SOLUTION NMR