6RFE

Human protein kinase CK2 alpha in complex with 2-cyano-2-propenamide compound 4

Summary for 6RFE

Entry DOI	10.2210/pdb6rfe/pdb
Related	6RB1 6RCB 6RCM
Descriptor	Casein kinase II subunit alpha, 1,2-ETHANEDIOL, (~{E})-~{N}-(5-bromanyl-1,3,4-thiadiazol-2-yl)-2-cyano-3-(3-methoxy-4-oxidanyl-phenyl)prop-2-enamide, ... (5 entities in total)
Functional Keywords	kinase domain, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40947.35
Authors	Dalle Vedove, A.,Zanforlin, E.,Ribaudo, G.,Zagotto, G.,Battistutta, R.,Lolli, G. (deposition date: 2019-04-13, release date: 2020-04-08, Last modification date: 2024-01-24)
Primary citation	Dalle Vedove, A.,Zonta, F.,Zanforlin, E.,Demitri, N.,Ribaudo, G.,Cazzanelli, G.,Ongaro, A.,Sarno, S.,Zagotto, G.,Battistutta, R.,Ruzzene, M.,Lolli, G. A novel class of selective CK2 inhibitors targeting its open hinge conformation. Eur.J.Med.Chem., 195:112267-112267, 2020 Cited by PubMed: 32283296 DOI: 10.1016/j.ejmech.2020.112267 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.54 Å)

Structure validation