6RCB

Human protein kinase CK2 alpha in complex with 2-cyano-2-propenamide compound 14

Summary for 6RCB

Entry DOI	10.2210/pdb6rcb/pdb
Related	6RB1
Descriptor	Casein kinase II subunit alpha, (~{E})-2-cyano-~{N}-(2-hydroxyphenyl)-3-(3-methoxy-4-oxidanyl-phenyl)prop-2-enamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	kinase domain, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40752.31
Authors	Dalle Vedove, A.,Lolli, G. (deposition date: 2019-04-11, release date: 2020-04-08, Last modification date: 2024-01-24)
Primary citation	Dalle Vedove, A.,Zonta, F.,Zanforlin, E.,Demitri, N.,Ribaudo, G.,Cazzanelli, G.,Ongaro, A.,Sarno, S.,Zagotto, G.,Battistutta, R.,Ruzzene, M.,Lolli, G. A novel class of selective CK2 inhibitors targeting its open hinge conformation. Eur.J.Med.Chem., 195:112267-112267, 2020 Cited by PubMed: 32283296 DOI: 10.1016/j.ejmech.2020.112267 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation