Summary for 6RAV
| Related | 6QSX 6QSW |
|---|---|
| Descriptor | Complement factor B, SULFATE ION, 4-[(2~{S},4~{S})-4-ethoxy-1-[(5-methoxy-7-methyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid, ... (5 entities in total) |
| Functional Keywords | complement, immune, inhibitor, c3 convertase, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total molecular weight | 67367.93 |
| Authors | Adams, C.M.,Sellner, H.,Ehara, T.,Mac Sweeney, A.,Crowley, M.,Anderson, K.,Karki, R.,Mainolfi, N.,Valeur, E.,Sirockin, F.,Gerhartz, B.,Erbel, P.,Hughes, N.,Smith, T.M.,Cumin, F.,Argikar, U.,Mogi, M.,Sedrani, R.,Wiesmann, C.,Jaffee, B.,Maibaum, J.,Flohr, S.,Harrison, R.,Eder, J. (deposition date: 2019-04-08, release date: 2019-04-17, Last modification date: 2019-10-30) |
| Primary citation | Schubart, A.,Anderson, K.,Mainolfi, N.,Sellner, H.,Ehara, T.,Adams, C.M.,Mac Sweeney, A.,Liao, S.M.,Crowley, M.,Littlewood-Evans, A.,Sarret, S.,Wieczorek, G.,Perrot, L.,Dubost, V.,Flandre, T.,Zhang, Y.,Smith, R.J.H.,Risitano, A.M.,Karki, R.G.,Zhang, C.,Valeur, E.,Sirockin, F.,Gerhartz, B.,Erbel, P.,Hughes, N.,Smith, T.M.,Cumin, F.,Argikar, U.A.,Haraldsson, B.,Mogi, M.,Sedrani, R.,Wiesmann, C.,Jaffee, B.,Maibaum, J.,Flohr, S.,Harrison, R.,Eder, J. Small-molecule factor B inhibitor for the treatment of complement-mediated diseases. Proc.Natl.Acad.Sci.USA, 116:7926-7931, 2019 PubMed: 30926668 (PDB entries with the same primary citation) DOI: 10.1073/pnas.1820892116  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
