6RA4

Human ARGONAUTE-2 PAZ DOMAIN (214-347) IN COMPLEX WITH CGUGACUCU

Summary for 6RA4

• Entry DOI: 10.2210/pdb6ra4/pdb
• Descriptor: Protein argonaute-2, RNA (5'-R(*CP*GP*UP*GP*AP*CP*UP*CP*U)-3'), GLYCEROL, ... (4 entities in total)
• Functional Keywords: sirna, paz domain, rna binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 37436.45

Authors

Rondeau, J.-M.,Bourgier, E. (deposition date: 2019-04-05, release date: 2019-05-08, Last modification date: 2024-05-15)

• Primary citation: Greenidge, P.A.,Blommers, M.J.J.,Priestle, J.P.,Hunziker, J.; How to Computationally Stack the Deck for Hit-to-Lead Generation: In Silico Molecular Interaction Energy Profiling for de Novo siRNA Guide Strand Surrogate Selection.; J.Chem.Inf.Model., 59:1897-1908, 2019; PubMed: 31021613; DOI: 10.1021/acs.jcim.8b00892

Experimental method

X-RAY DIFFRACTION (1.9 Å)