6R7D
Crystal structure of LTC4S in complex with AZ13690257
Summary for 6R7D
Entry DOI | 10.2210/pdb6r7d/pdb |
Descriptor | Leukotriene C4 synthase, (1~{S},2~{S})-2-[5-[cyclopropylmethyl(naphthalen-1-yl)amino]-4-methoxy-pyrimidin-2-yl]carbonylcyclopropane-1-carboxylic acid, NICKEL (II) ION, ... (6 entities in total) |
Functional Keywords | inhibitor, arachidonic acid cascade, cysteinyl leukotrienes, membrane protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 12 |
Total formula weight | 226807.33 |
Authors | |
Primary citation | Munck Af Rosenschold, M.,Johannesson, P.,Nikitidis, A.,Tyrchan, C.,Chang, H.F.,Ronn, R.,Chapman, D.,Ullah, V.,Nikitidis, G.,Glader, P.,Kack, H.,Bonn, B.,Wagberg, F.,Bjorkstrand, E.,Andersson, U.,Swedin, L.,Rohman, M.,Andreasson, T.,Bergstrom, E.L.,Jiang, F.,Zhou, X.H.,Lundqvist, A.J.,Malmberg, A.,Ek, M.,Gordon, E.,Pettersen, A.,Ripa, L.,Davis, A.M. Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma. J.Med.Chem., 62:7769-7787, 2019 Cited by PubMed: 31415176DOI: 10.1021/acs.jmedchem.9b00555 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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