6R6W

Structure of recombinant human butyrylcholinesterase in complex with a fluorescent NBD-based probe

Summary for 6R6W

Entry DOI	10.2210/pdb6r6w/pdb
Descriptor	Cholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	butyrylcholinesterase, protein-ligand complex, fluorescent probe, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	62849.64
Authors	Brazzolotto, X.,Nachon, F.,Knez, D.,Gobec, S. (deposition date: 2019-03-28, release date: 2020-01-15, Last modification date: 2024-01-24)
Primary citation	Pajk, S.,Knez, D.,Kosak, U.,Zorovic, M.,Brazzolotto, X.,Coquelle, N.,Nachon, F.,Colletier, J.P.,Zivin, M.,Stojan, J.,Gobec, S. Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes. J Enzyme Inhib Med Chem, 35:498-505, 2020 Cited by PubMed: 31914836 DOI: 10.1080/14756366.2019.1710502 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.474 Å)

Structure validation