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6R6W

Structure of recombinant human butyrylcholinesterase in complex with a fluorescent NBD-based probe

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Cholinesterasepolymer52659354.21UniProt (P06276)
Pfam (PF00135)
Homo sapiens (Human)Acylcholine acylhydrolase,Butyrylcholine esterase,Choline esterase II,Pseudocholinesterase
2B
(B)
alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched367.31In PDB
GlyTouCan (G86851RC)
3C, D
(C, D)
2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranosebranched570.52In PDB
GlyTouCan (G21290RB)
4E, F, G
(A)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.23Chemie (NAG)
5H
(A)
[7-[4-[2-[naphthalen-2-ylsulfonyl-[[(3~{S})-1-(phenylmethyl)piperidin-1-ium-3-yl]methyl]amino]ethyl]piperazin-4-ium-1-yl]-2,1,3-benzoxadiazol-4-yl]-oxidanyl-oxidanylidene-azaniumnon-polymer672.81Chemie (JUB)
6I
(A)
GLYCEROLnon-polymer92.11Chemie (GOL)
7J, K, L, M, N
(A)
SULFATE IONnon-polymer96.15Chemie (SO4)
8O
(A)
DIMETHYL SULFOXIDEnon-polymer78.11Chemie (DMS)
9P
(A)
waterwater18.091Chemie (HOH)
Sequence modifications
A: 4 - 529 (UniProt: P06276)
PDBExternal DatabaseDetails
Gln 17Asn 45engineered mutation
Gln 455Asn 483engineered mutation
Gln 481Asn 509engineered mutation
Gln 486Asn 514engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight59354.2
BranchedNumber of molecules3
Total formula weight1508.4
Non-Polymers*Number of molecules11
Total formula weight1987.0
All*Total formula weight62849.6
*Water molecules are not included.

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PDB entries from 2025-07-23

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