6R5H

Major aspartyl peptidase 1 from C. neoformans

Summary for 6R5H

Entry DOI	10.2210/pdb6r5h/pdb
Descriptor	Endopeptidase, PENTAETHYLENE GLYCOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
Functional Keywords	aspartyl protease, secreted, cryptococcus neoformans, hydrolase
Biological source	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)
Total number of polymer chains	1
Total formula weight	39113.55
Authors	Krystufek, R.,Sacha, P.,Brynda, J.,Konvalinka, J. (deposition date: 2019-03-25, release date: 2021-04-07, Last modification date: 2021-06-09)
Primary citation	Krystufek, R.,Sacha, P.,Starkova, J.,Brynda, J.,Hradilek, M.,Tloust'ova, E.,Grzymska, J.,Rut, W.,Boucher, M.J.,Drag, M.,Majer, P.,Hajek, M.,Rezacova, P.,Madhani, H.D.,Craik, C.S.,Konvalinka, J. Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery. J.Med.Chem., 64:6706-6719, 2021 Cited by PubMed: 34006103 DOI: 10.1021/acs.jmedchem.0c02177 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation