6R59

Crystal structure of PPEP-1(E143A/Y178F) in complex with substrate peptide Ac-EVAPPVP-NH2

Summary for 6R59

Entry DOI	10.2210/pdb6r59/pdb
Descriptor	Pro-Pro endopeptidase, ACE-GLU-VAL-ALA-PRO-PRO-VAL-LPD, ZINC ION, ... (4 entities in total)
Functional Keywords	pro-pro endopeptidase 1, zinc metallopeptidase, clostridium difficile, virulence factor, hydrolase
Biological source	Peptoclostridium difficile More
Total number of polymer chains	4
Total formula weight	45241.69
Authors	Pichlo, C.,Baumann, U. (deposition date: 2019-03-24, release date: 2019-06-12, Last modification date: 2024-01-24)
Primary citation	Pichlo, C.,Juetten, L.,Wojtalla, F.,Schacherl, M.,Diaz, D.,Baumann, U. Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1. J.Biol.Chem., 294:11525-11535, 2019 Cited by PubMed: 31182482 DOI: 10.1074/jbc.RA119.009029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation