6R2W

Crystal structure of the super-active FVIIa variant VYT in complex with tissue factor

6R2W の概要

• エントリーDOI: 10.2210/pdb6r2w/pdb
• 分子名称: Coagulation factor VII, Tissue factor, alpha-D-xylopyranose-(1-3)-alpha-D-xylopyranose-(1-3)-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: trypsin-fold, protein-protein complex, hydrolase, coagulation factor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 70019.71

構造登録者

Sorensen, A.B.,Svensson, L.A.,Gandhi, P.S. (登録日: 2019-03-19, 公開日: 2019-12-11, 最終更新日: 2024-01-24)

• 主引用文献: Sorensen, A.B.,Tuneew, I.,Svensson, L.A.,Persson, E.,Ostergaard, H.,Overgaard, M.T.,Olsen, O.H.,Gandhi, P.S.; Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa.; J.Biol.Chem., 295:517-528, 2020; PubMed: 31801825; DOI: 10.1074/jbc.RA119.009183

実験手法

X-RAY DIFFRACTION (1.25 Å)