6R2Q

Structure of the Mtr complex

6R2Q の概要

• エントリーDOI: 10.2210/pdb6r2q/pdb
• 関連するPDBエントリー: 6QYC
• 分子名称: Cystathionine beta-synthase, Uncharacterized protein, Decaheme c-type cytochrome, OmcA/MtrC family, ... (6 entities in total)
• 機能のキーワード: cytochrome, membrane protein, greek key, multiheme, electron transport
• 由来する生物種: Shewanella baltica; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 194121.75

構造登録者

Clarke, T.A.,Edwards, M.J. (登録日: 2019-03-18, 公開日: 2020-04-22, 最終更新日: 2020-05-13)

主引用文献

Edwards, M.J.,White, G.F.,Butt, J.N.,Richardson, D.J.,Clarke, T.A.
The Crystal Structure of a Biological Insulated Transmembrane Molecular Wire.
Cell, 181:665-673.e10, 2020

PubMed Abstract: A growing number of bacteria are recognized to conduct electrons across their cell envelope, and yet molecular details of the mechanisms supporting this process remain unknown. Here, we report the atomic structure of an outer membrane spanning protein complex, MtrAB, that is representative of a protein family known to transport electrons between the interior and exterior environments of phylogenetically and metabolically diverse microorganisms. The structure is revealed as a naturally insulated biomolecular wire possessing a 10-heme cytochrome, MtrA, insulated from the membrane lipidic environment by embedding within a 26 strand β-barrel formed by MtrB. MtrAB forms an intimate connection with an extracellular 10-heme cytochrome, MtrC, which presents its hemes across a large surface area for electrical contact with extracellular redox partners, including transition metals and electrodes.

PubMed: 32289252
DOI: 10.1016/j.cell.2020.03.032

実験手法

X-RAY DIFFRACTION (2.697 Å)