6R2E
Crystal structure of the human thymidylate synthase (hTS) interface variant Q62R
Summary for 6R2E
Entry DOI | 10.2210/pdb6r2e/pdb |
Descriptor | Thymidylate synthase, SULFATE ION, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ... (7 entities in total) |
Functional Keywords | human thymidylate synthase, folate pathway, q62r, interface variant, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 304626.38 |
Authors | Pozzi, C.,Mangani, M. (deposition date: 2019-03-16, release date: 2019-04-10, Last modification date: 2024-01-24) |
Primary citation | Pozzi, C.,Lopresti, L.,Santucci, M.,Costi, M.P.,Mangani, S. Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R. Biomolecules, 9:-, 2019 Cited by PubMed: 30987202DOI: 10.3390/biom9040134 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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