6R2E

Crystal structure of the human thymidylate synthase (hTS) interface variant Q62R

Summary for 6R2E

• Entry DOI: 10.2210/pdb6r2e/pdb
• Descriptor: Thymidylate synthase, SULFATE ION, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ... (7 entities in total)
• Functional Keywords: human thymidylate synthase, folate pathway, q62r, interface variant, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 304626.38

Authors

Pozzi, C.,Mangani, M. (deposition date: 2019-03-16, release date: 2019-04-10, Last modification date: 2024-01-24)

• Primary citation: Pozzi, C.,Lopresti, L.,Santucci, M.,Costi, M.P.,Mangani, S.; Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R.; Biomolecules, 9:-, 2019; PubMed: 30987202; DOI: 10.3390/biom9040134

Experimental method

X-RAY DIFFRACTION (2.55 Å)