6R2A

Crystal structure of the SucA domain of Mycobacterium smegmatis KGD cocrystallized with succinylphosphonate phosphonoethyl ester (PESP)

6R2A の概要

• エントリーDOI: 10.2210/pdb6r2a/pdb
• 分子名称: Multifunctional 2-oxoglutarate metabolism enzyme, (4~{S})-4-[(2~{R})-3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl(phosphonooxy)phosphoryl]oxyethyl]-2~{H}-1,3-thiazol-2-yl]-4-[ethoxy(oxidanyl)phosphoryl]-4-oxidanyl-butanoic acid, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: oxoglutarate dehydrogenase, tpp-dependent decarboxylase, oxidoreductase
• 由来する生物種: Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 196412.45

構造登録者

Wagner, T.,Alzari, P.M.,Bellinzoni, M. (登録日: 2019-03-15, 公開日: 2019-09-11, 最終更新日: 2024-01-24)

• 主引用文献: Wagner, T.,Boyko, A.,Alzari, P.M.,Bunik, V.I.,Bellinzoni, M.; Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts.; J.Struct.Biol., 208:182-190, 2019; PubMed: 31476368; DOI: 10.1016/j.jsb.2019.08.012

実験手法