6R1O

Crystal structure of E. coli seryl-tRNA synthetase complexed to a seryl sulfamoyl adenosine derivative

6R1O の概要

• エントリーDOI: 10.2210/pdb6r1o/pdb
• 分子名称: Serine--tRNA ligase, [(2~{R},3~{S},4~{R},5~{R})-5-(6-azanyl-2-pyridin-3-yl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-oxidanyl-propanoyl]sulfamate, CHLORIDE ION, ... (8 entities in total)
• 機能のキーワード: aminoacyl-trna synthetase, class ii, protein synthesis, inhibitor, ligase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51893.45

構造登録者

Salimraj, R.,Cain, R.,Roper, D.I. (登録日: 2019-03-14, 公開日: 2020-01-22, 最終更新日: 2024-01-24)

• 主引用文献: Cain, R.,Salimraj, R.,Punekar, A.S.,Bellini, D.,Fishwick, C.W.G.,Czaplewski, L.,Scott, D.J.,Harris, G.,Dowson, C.G.,Lloyd, A.J.,Roper, D.I.; Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase.; J.Med.Chem., 62:9703-9717, 2019; PubMed: 31626547; DOI: 10.1021/acs.jmedchem.9b01131

実験手法

X-RAY DIFFRACTION (2.6 Å)