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6R1M

Crystal structure of E. coli seryl-tRNA synthetase complexed to seryl sulfamoyl adenosine

Summary for 6R1M
Entry DOI10.2210/pdb6r1m/pdb
DescriptorSerine--tRNA ligase, 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordsaminoacyl-trna synthetase, class ii, protein synthesis, inhibitor, ligase
Biological sourceEscherichia coli
Total number of polymer chains2
Total formula weight100817.62
Authors
Salimraj, R.,Cain, R.,Roper, D.I. (deposition date: 2019-03-14, release date: 2020-01-22, Last modification date: 2024-01-24)
Primary citationCain, R.,Salimraj, R.,Punekar, A.S.,Bellini, D.,Fishwick, C.W.G.,Czaplewski, L.,Scott, D.J.,Harris, G.,Dowson, C.G.,Lloyd, A.J.,Roper, D.I.
Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase.
J.Med.Chem., 62:9703-9717, 2019
Cited by
PubMed: 31626547
DOI: 10.1021/acs.jmedchem.9b01131
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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