6R1K
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 7c
Summary for 6R1K
| Entry DOI | 10.2210/pdb6r1k/pdb |
| Descriptor | Cereblon isoform 4, ZINC ION, ~{N}-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]-2,4,6-tris(chloranyl)benzamide, ... (5 entities in total) |
| Functional Keywords | proteolysis targeting chimera, protac, protein degradation, signaling protein |
| Biological source | Magnetospirillum gryphiswaldense MSR-1 |
| Total number of polymer chains | 3 |
| Total formula weight | 42688.10 |
| Authors | Heim, C.,Hartmann, M.D. (deposition date: 2019-03-14, release date: 2019-08-07, Last modification date: 2024-01-24) |
| Primary citation | Heim, C.,Pliatsika, D.,Mousavizadeh, F.,Bar, K.,Hernandez Alvarez, B.,Giannis, A.,Hartmann, M.D. De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. J.Med.Chem., 62:6615-6629, 2019 Cited by PubMed: 31251063DOI: 10.1021/acs.jmedchem.9b00454 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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