6R1D
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 7d, co-crystallized
Summary for 6R1D
Entry DOI | 10.2210/pdb6r1d/pdb |
Descriptor | Cereblon isoform 4, ZINC ION, (phenylmethyl) ~{N}-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]carbamate, ... (4 entities in total) |
Functional Keywords | proteolysis targeting chimera, protac, protein degradation, signaling protein |
Biological source | Magnetospirillum gryphiswaldense MSR-1 |
Total number of polymer chains | 2 |
Total formula weight | 28034.44 |
Authors | Heim, C.,Hartmann, M.D. (deposition date: 2019-03-14, release date: 2019-08-07, Last modification date: 2024-01-24) |
Primary citation | Heim, C.,Pliatsika, D.,Mousavizadeh, F.,Bar, K.,Hernandez Alvarez, B.,Giannis, A.,Hartmann, M.D. De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. J.Med.Chem., 62:6615-6629, 2019 Cited by PubMed: 31251063DOI: 10.1021/acs.jmedchem.9b00454 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
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