6R08

T. cruzi FPPS in complex with 3-(carboxymethyl)-5,7-dichloro-1H-indole-2-carboxylic acid

Summary for 6R08

• Entry DOI: 10.2210/pdb6r08/pdb
• Descriptor: Farnesyl diphosphate synthase, 3-(carboxymethyl)-5,7-dichloro-1H-indole-2-carboxylic acid, ZINC ION, ... (5 entities in total)
• Functional Keywords: farnesyl diphosphate synthase, sterol biosynthesis, farnesyl pyrophosphate, homodimer, transferase
• Biological source: Trypanosoma cruzi
• Total number of polymer chains: 1
• Total formula weight: 41874.54

Authors

Petrick, J.K.,Muenzker, L.,Schleberger, C.,Jahnke, W. (deposition date: 2019-03-12, release date: 2020-04-01, Last modification date: 2024-02-07)

• Primary citation: Petrick, J.K.,Jahnke, W.; Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery; Thesis, 2019; DOI: 10.17192/z2019.0501

Experimental method

X-RAY DIFFRACTION (1.44 Å)