6QZH

Structure of the human CC Chemokine Receptor 7 in complex with the intracellular allosteric antagonist Cmp2105 and the insertion protein Sialidase NanA

Summary for 6QZH

Entry DOI	10.2210/pdb6qzh/pdb
Descriptor	C-C chemokine receptor type 7,Sialidase A,C-C chemokine receptor type 7, TRIETHYLENE GLYCOL, 3-[[4-[[(1~{R})-2,2-dimethyl-1-(5-methylfuran-2-yl)propyl]amino]-1,1-bis(oxidanylidene)-1,2,5-thiadiazol-3-yl]amino]-~{N},~{N},6-trimethyl-2-oxidanyl-benzamide, ... (6 entities in total)
Functional Keywords	gpcr, chemokine receptor, small molecule, allosteric modulator, insertion protein, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	89289.41
Authors	Jaeger, K.,Bruenle, S.,Weinert, T.,Guba, W.,Muehle, J.,Miyazaki, T.,Weber, M.,Furrer, A.,Haenggi, N.,Tetaz, T.,Huang, C.Y.,Mattle, D.,Vonach, J.M.,Gast, A.,Kuglstatter, A.,Rudolph, M.G.,Nogly, P.,Benz, J.,Dawson, R.J.P.,Standfuss, J. (deposition date: 2019-03-11, release date: 2019-09-04, Last modification date: 2024-01-24)
Primary citation	Jaeger, K.,Bruenle, S.,Weinert, T.,Guba, W.,Muehle, J.,Miyazaki, T.,Weber, M.,Furrer, A.,Haenggi, N.,Tetaz, T.,Huang, C.Y.,Mattle, D.,Vonach, J.M.,Gast, A.,Kuglstatter, A.,Rudolph, M.G.,Nogly, P.,Benz, J.,Dawson, R.J.P.,Standfuss, J. Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7. Cell, 178:1222-1230.e10, 2019 Cited by PubMed: 31442409 DOI: 10.1016/j.cell.2019.07.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation