6QZH

Structure of the human CC Chemokine Receptor 7 in complex with the intracellular allosteric antagonist Cmp2105 and the insertion protein Sialidase NanA

6QZH の概要

• エントリーDOI: 10.2210/pdb6qzh/pdb
• 分子名称: C-C chemokine receptor type 7,Sialidase A,C-C chemokine receptor type 7, TRIETHYLENE GLYCOL, 3-[[4-[[(1~{R})-2,2-dimethyl-1-(5-methylfuran-2-yl)propyl]amino]-1,1-bis(oxidanylidene)-1,2,5-thiadiazol-3-yl]amino]-~{N},~{N},6-trimethyl-2-oxidanyl-benzamide, ... (6 entities in total)
• 機能のキーワード: gpcr, chemokine receptor, small molecule, allosteric modulator, insertion protein, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 89289.41

構造登録者

Jaeger, K.,Bruenle, S.,Weinert, T.,Guba, W.,Muehle, J.,Miyazaki, T.,Weber, M.,Furrer, A.,Haenggi, N.,Tetaz, T.,Huang, C.Y.,Mattle, D.,Vonach, J.M.,Gast, A.,Kuglstatter, A.,Rudolph, M.G.,Nogly, P.,Benz, J.,Dawson, R.J.P.,Standfuss, J. (登録日: 2019-03-11, 公開日: 2019-09-04, 最終更新日: 2024-01-24)

• 主引用文献: Jaeger, K.,Bruenle, S.,Weinert, T.,Guba, W.,Muehle, J.,Miyazaki, T.,Weber, M.,Furrer, A.,Haenggi, N.,Tetaz, T.,Huang, C.Y.,Mattle, D.,Vonach, J.M.,Gast, A.,Kuglstatter, A.,Rudolph, M.G.,Nogly, P.,Benz, J.,Dawson, R.J.P.,Standfuss, J.; Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7.; Cell, 178:1222-1230.e10, 2019; PubMed: 31442409; DOI: 10.1016/j.cell.2019.07.028

実験手法

X-RAY DIFFRACTION (2.1 Å)