6QYQ
Crystal structure of human thymidylate synthase (hTS) variant R175C
Summary for 6QYQ
Entry DOI | 10.2210/pdb6qyq/pdb |
Descriptor | Thymidylate synthase, SULFATE ION, CHLORIDE ION, ... (8 entities in total) |
Functional Keywords | human thymidylate synthase, folate pathway, r175c, interface variant, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 150767.63 |
Authors | Pozzi, C.,Mangani, M. (deposition date: 2019-03-09, release date: 2019-04-17, Last modification date: 2024-01-24) |
Primary citation | Pozzi, C.,Ferrari, S.,Luciani, R.,Costi, M.P.,Mangani, S. Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors. Molecules, 24:-, 2019 Cited by PubMed: 30959951DOI: 10.3390/molecules24071362 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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