6QYQ

Crystal structure of human thymidylate synthase (hTS) variant R175C

Summary for 6QYQ

Entry DOI	10.2210/pdb6qyq/pdb
Descriptor	Thymidylate synthase, SULFATE ION, CHLORIDE ION, ... (8 entities in total)
Functional Keywords	human thymidylate synthase, folate pathway, r175c, interface variant, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	150767.63
Authors	Pozzi, C.,Mangani, M. (deposition date: 2019-03-09, release date: 2019-04-17, Last modification date: 2024-01-24)
Primary citation	Pozzi, C.,Ferrari, S.,Luciani, R.,Costi, M.P.,Mangani, S. Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors. Molecules, 24:-, 2019 Cited by PubMed: 30959951 DOI: 10.3390/molecules24071362 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation