Summary for 6QXU
| Descriptor | Poly [ADP-ribose] polymerase tankyrase-1, BETA-MERCAPTOETHANOL, 6,8-bis(fluoranyl)-2-[4-(2-oxidanylpropan-2-yl)phenyl]-3~{H}-quinazolin-4-one, ... (5 entities in total) |
|---|---|
| Functional Keywords | tankyrase, parp, inhibitor, transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total molecular weight | 24672.3 |
| Authors | |
| Primary citation | Buchstaller, H.P.,Anlauf, U.,Dorsch, D.,Kuhn, D.,Lehmann, M.,Leuthner, B.,Musil, D.,Radtki, D.,Ritzert, C.,Rohdich, F.,Schneider, R.,Esdar, C. Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity. J.Med.Chem., 2019 PubMed: 31381853 (PDB entries with the same primary citation) DOI: 10.1021/acs.jmedchem.9b00656  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (1.2 Å) |
