6QVL
Human SHMT2 in complex with pemetrexed
Summary for 6QVL
Entry DOI | 10.2210/pdb6qvl/pdb |
Descriptor | Serine hydroxymethyltransferase, mitochondrial, GLYCEROL, DI(HYDROXYETHYL)ETHER, ... (7 entities in total) |
Functional Keywords | transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 113477.92 |
Authors | Scaletti, E.,Jemth, A.S.,Helleday, T.,Stenmark, P. (deposition date: 2019-03-03, release date: 2019-09-04) |
Primary citation | Scaletti, E.,Jemth, A.S.,Helleday, T.,Stenmark, P. Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs. Febs Lett., 593:1863-1873, 2019 Cited by PubMed: 31127856DOI: 10.1002/1873-3468.13455 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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