6QUX
Crystal Structure of KRAS-G12D in Complex with Natural Product-Like Compound 15
Summary for 6QUX
Entry DOI | 10.2210/pdb6qux/pdb |
Descriptor | GTPase KRas, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | ppi, kras, gtpase, cancer, oncoprotein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 40336.31 |
Authors | Fischer, G.,Kessler, D.,Muellauer, B.,Wolkerstorfer, B. (deposition date: 2019-02-28, release date: 2019-07-31, Last modification date: 2024-05-15) |
Primary citation | Bergner, A.,Cockcroft, X.,Fischer, G.,Gollner, A.,Hela, W.,Kousek, R.,Mantoulidis, A.,Martin, L.J.,Mayer, M.,Mullauer, B.,Siszler, G.,Wolkerstorfer, B.,Kessler, D.,McConnell, D.B. KRAS Binders Hidden in Nature. Chemistry, 25:12037-12041, 2019 Cited by PubMed: 31231840DOI: 10.1002/chem.201902810 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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