6QU5

Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric inhibitor ctcb12

6QU5 の概要

• エントリーDOI: 10.2210/pdb6qu5/pdb
• 分子名称: ATP-dependent 6-phosphofructokinase, CITRIC ACID, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: glycolysis, inhibitor, allostery, transferase
• 由来する生物種: Trypanosoma brucei brucei
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 448293.02

構造登録者

McNae, I.W.,Dornan, J.,Walkinshaw, M.D. (登録日: 2019-02-26, 公開日: 2020-03-18, 最終更新日: 2024-01-24)

• 主引用文献: McNae, I.W.,Kinkead, J.,Malik, D.,Yen, L.H.,Walker, M.K.,Swain, C.,Webster, S.P.,Gray, N.,Fernandes, P.M.,Myburgh, E.,Blackburn, E.A.,Ritchie, R.,Austin, C.,Wear, M.A.,Highton, A.J.,Keats, A.J.,Vong, A.,Dornan, J.,Mottram, J.C.,Michels, P.A.M.,Pettit, S.,Walkinshaw, M.D.; Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice.; Nat Commun, 12:1052-1052, 2021; PubMed: 33594070; DOI: 10.1038/s41467-021-21273-6

実験手法

X-RAY DIFFRACTION (3.4 Å)