6QU4
Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric inhibitor ctcb405
Summary for 6QU4
Entry DOI | 10.2210/pdb6qu4/pdb |
Descriptor | ATP-dependent 6-phosphofructokinase, 1-[(3,4-dichlorophenyl)methyl]-5-[2-(dimethylamino)ethyl]pyrrolo[3,2-c]pyridin-4-one, CITRIC ACID, ... (5 entities in total) |
Functional Keywords | glycolysis, inhibitor, allostery, transferase |
Biological source | Trypanosoma brucei brucei |
Total number of polymer chains | 4 |
Total formula weight | 225652.78 |
Authors | McNae, I.W.,Dornan, J.,Walkinshaw, M.D. (deposition date: 2019-02-26, release date: 2020-03-18, Last modification date: 2024-01-24) |
Primary citation | McNae, I.W.,Kinkead, J.,Malik, D.,Yen, L.H.,Walker, M.K.,Swain, C.,Webster, S.P.,Gray, N.,Fernandes, P.M.,Myburgh, E.,Blackburn, E.A.,Ritchie, R.,Austin, C.,Wear, M.A.,Highton, A.J.,Keats, A.J.,Vong, A.,Dornan, J.,Mottram, J.C.,Michels, P.A.M.,Pettit, S.,Walkinshaw, M.D. Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice. Nat Commun, 12:1052-1052, 2021 Cited by PubMed: 33594070DOI: 10.1038/s41467-021-21273-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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