6QU4
Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric inhibitor ctcb405
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | ATP-dependent 6-phosphofructokinase | polymer | 507 | 55764.7 | 4 | UniProt (O15648) Pfam (PF00365) In PDB | Trypanosoma brucei brucei | Phosphofructokinase,Phosphohexokinase |
2 | A, B, C, D | 1-[(3,4-dichlorophenyl)methyl]-5-[2-(dimethylamino)ethyl]pyrrolo[3,2-c]pyridin-4-one | non-polymer | 364.3 | 4 | Chemie (JJ2) | |||
3 | A, B, C, D | CITRIC ACID | non-polymer | 192.1 | 4 | Chemie (CIT) | |||
4 | A, B, C, D | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
5 | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 487 (UniProt: O15648)
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 223058.8 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 2593.9 | |
All* | Total formula weight | 225652.8 |