6QS9
Bovine Serum Albumin in complex with Ketoprofen
Summary for 6QS9
| Entry DOI | 10.2210/pdb6qs9/pdb |
| Descriptor | Serum albumin, (R)-Ketoprofen, CALCIUM ION, ... (4 entities in total) |
| Functional Keywords | non-steroidal anti-inflammatory drug, plasma protein, transport protein |
| Biological source | Bos taurus (Cattle) |
| Total number of polymer chains | 2 |
| Total formula weight | 139461.67 |
| Authors | Donini, S.,Parisini, E. (deposition date: 2019-02-20, release date: 2019-09-11, Last modification date: 2024-10-16) |
| Primary citation | Castagna, R.,Donini, S.,Colnago, P.,Serafini, A.,Parisini, E.,Bertarelli, C. Biohybrid Electrospun Membrane for the Filtration of Ketoprofen Drug from Water. Acs Omega, 4:13270-13278, 2019 Cited by PubMed Abstract: A current challenge in materials science and biotechnology is to express a specific and controlled functionality on the large interfacial area of a nanostructured material to create smart biohybrid systems for targeted applications. Here, we report on a biohybrid system featuring poly(vinyl alcohol) as the supporting synthetic polymer and bovine serum albumin as the biofunctional element. The optimal processing conditions to produce these self-standing composite membranes are determined, and the composition and distribution of the bioactive agent within the polymeric matrices are analyzed. A post-processing cross-linking using glutaraldehyde enables this functional membrane to be used as a chemical filter in aqueous environments. By demonstrating that our mats can remove large amounts of ketoprofen from water, we show that the combination of a BSA-induced biofunctionality with a nanostructured fibrous material allows for the development of an efficient biohybrid filtering device for the large and widely used family of nonsteroidal anti-inflammatory drugs (NSAIDs). The crystal structure of the complex between BSA and ketoprofen is determined for the first time and confirms the interaction between the two species. PubMed: 31460455DOI: 10.1021/acsomega.9b01442 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.802 Å) |
Structure validation
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