6QS0
NMR structure of BB_A03, Borrelia burgdorferi outer surface lipoprotein
Summary for 6QS0
| Entry DOI | 10.2210/pdb6qs0/pdb |
| NMR Information | BMRB: 34361 |
| Descriptor | Putative outer membrane protein BBA03 (1 entity in total) |
| Functional Keywords | lipoprotein, membrane protein |
| Biological source | Borreliella burgdorferi B31 |
| Total number of polymer chains | 1 |
| Total formula weight | 13746.59 |
| Authors | Fridmanis, J.,Brangulis, K.,Jaudzems, K. (deposition date: 2019-02-20, release date: 2020-03-18, Last modification date: 2024-06-19) |
| Primary citation | Fridmanis, J.,Bobrovs, R.,Brangulis, K.,Tars, K.,Jaudzems, K. Structural and Functional Analysis of BBA03, Borrelia burgdorferi Competitive Advantage Promoting Outer Surface Lipoprotein. Pathogens, 9:-, 2020 Cited by PubMed Abstract: BBA03 is a outer surface lipoprotein encoded on one of the most conserved plasmids in genome, linear plasmid 54 (lp54). Although many of its genes have been identified as contributing or essential for spirochete fitness in vivo, the majority of the proteins encoded on this plasmid have no known function and lack homologs in other organisms. In this paper, we report the solution NMR structure of the outer surface lipoprotein BBA03, which is known to provide a competitive advantage to the bacteria during the transmission from tick vector to mammalian host. BBA03 shows structural homology to other outer surface lipoproteins reflecting their genetic and evolutionary relatedness. Analysis of the structure reveals a pore in BBA03, which could potentially bind lipids. PubMed: 33050189DOI: 10.3390/pathogens9100826 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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