6QRD
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with inhibitor
Summary for 6QRD
Entry DOI | 10.2210/pdb6qrd/pdb |
Related | 6NVR |
Descriptor | tRNA (guanine-N(1)-)-methyltransferase, SULFATE ION, 5-azanyl-3-[1-[[4-[(4-propan-2-ylpiperazin-1-yl)methyl]phenyl]methyl]indol-6-yl]-1~{H}-pyrazole-4-carbonitrile, ... (4 entities in total) |
Functional Keywords | trmd, trna methyltransferase, spout methyltransferase, transferase |
Biological source | Mycobacterium abscessus |
Total number of polymer chains | 2 |
Total formula weight | 54064.69 |
Authors | Thomas, S.E.,Whitehouse, A.J.,Coyne, A.G.,Abell, C.,Mendes, V.,Blundell, T.L. (deposition date: 2019-02-19, release date: 2019-09-18, Last modification date: 2024-01-24) |
Primary citation | Whitehouse, A.J.,Thomas, S.E.,Brown, K.P.,Fanourakis, A.,Chan, D.S.,Libardo, M.D.J.,Mendes, V.,Boshoff, H.I.M.,Floto, R.A.,Abell, C.,Blundell, T.L.,Coyne, A.G. Development of Inhibitors againstMycobacterium abscessustRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches. J.Med.Chem., 62:7210-7232, 2019 Cited by PubMed: 31282680DOI: 10.1021/acs.jmedchem.9b00809 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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