6QRC

Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with inhibitor

Summary for 6QRC

Entry DOI	10.2210/pdb6qrc/pdb
Related	6NVR
Descriptor	tRNA (guanine-N(1)-)-methyltransferase, 3-[1-[(3-methoxyphenyl)methyl]indol-6-yl]-1~{H}-pyrazol-5-amine, SULFATE ION, ... (4 entities in total)
Functional Keywords	trmd, trna methyltransferase, spout methyltransferase, transferase
Biological source	Mycobacterium abscessus
Total number of polymer chains	2
Total formula weight	53602.15
Authors	Thomas, S.E.,Whitehouse, A.J.,Coyne, A.G.,Abell, C.,Mendes, V.,Blundell, T.L. (deposition date: 2019-02-19, release date: 2019-09-18, Last modification date: 2024-01-24)
Primary citation	Whitehouse, A.J.,Thomas, S.E.,Brown, K.P.,Fanourakis, A.,Chan, D.S.,Libardo, M.D.J.,Mendes, V.,Boshoff, H.I.M.,Floto, R.A.,Abell, C.,Blundell, T.L.,Coyne, A.G. Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches. J.Med.Chem., 62:7210-7232, 2019 Cited by PubMed: 31282680 DOI: 10.1021/acs.jmedchem.9b00809 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation