6QRB

Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with inhibitor

Summary for 6QRB

• Entry DOI: 10.2210/pdb6qrb/pdb
• Related: 6NVR
• Descriptor: tRNA (guanine-N(1)-)-methyltransferase, 5-azanyl-3-[1-[[(3~{R})-1-(phenylmethyl)piperidin-3-yl]methyl]indol-6-yl]-1~{H}-pyrazole-4-carbonitrile (3 entities in total)
• Functional Keywords: trmd, trna methyltransferase, spout methyltransferase, transferase
• Biological source: Mycobacterium abscessus
• Total number of polymer chains: 2
• Total formula weight: 53690.37

Authors

Thomas, S.E.,Whitehouse, A.J.,Coyne, A.G.,Abell, C.,Mendes, V.,Blundell, T.L. (deposition date: 2019-02-19, release date: 2020-03-18, Last modification date: 2024-01-24)

• Primary citation: Whitehouse, A.J.,Thomas, S.E.,Brown, K.P.,Fanourakis, A.,Chan, D.S.,Libardo, M.D.J.,Mendes, V.,Boshoff, H.I.M.,Floto, R.A.,Abell, C.,Blundell, T.L.,Coyne, A.G.; Development of Inhibitors against Mycobacterium abscessus tRNA (m 1 G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.; J.Med.Chem., 62:7210-7232, 2019; PubMed: 31282680; DOI: 10.1021/acs.jmedchem.9b00809

Experimental method

X-RAY DIFFRACTION (1.66 Å)