6QM0

Cathepsin-K in complex with amino-oxaazabicyclo[3.3.0]octanyl containing inhibitor

Summary for 6QM0

• Entry DOI: 10.2210/pdb6qm0/pdb
• Related: 6QL8
• Descriptor: Cathepsin K, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, ~{N}-[(2~{S})-1-[(3~{R},3~{a}~{R},6~{R},6~{a}~{R})-6-azanyl-3-oxidanyl-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxidanylidene-pentan-2-yl]-3-fluoranyl-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide, ... (4 entities in total)
• Functional Keywords: inhibitor complex, lysosomal cysteine proteinase, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 48672.87

Authors

Derbyshire, D.J. (deposition date: 2019-02-01, release date: 2020-02-19)

• Primary citation: Derbyshire, D.J.; Successful development of 3-oxohexahydrofuropyrrole amino acid amides as inhibitors of Cathepsin-K.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)