6QM0

Cathepsin-K in complex with amino-oxaazabicyclo[3.3.0]octanyl containing inhibitor

6QM0 の概要

• エントリーDOI: 10.2210/pdb6qm0/pdb
• 関連するPDBエントリー: 6QL8
• 分子名称: Cathepsin K, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, ~{N}-[(2~{S})-1-[(3~{R},3~{a}~{R},6~{R},6~{a}~{R})-6-azanyl-3-oxidanyl-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxidanylidene-pentan-2-yl]-3-fluoranyl-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide, ... (4 entities in total)
• 機能のキーワード: inhibitor complex, lysosomal cysteine proteinase, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48672.87

構造登録者

Derbyshire, D.J. (登録日: 2019-02-01, 公開日: 2020-02-19)

• 主引用文献: Derbyshire, D.J.; Successful development of 3-oxohexahydrofuropyrrole amino acid amides as inhibitors of Cathepsin-K.; To Be Published,

実験手法

X-RAY DIFFRACTION (1.9 Å)