6QL3
Crystal structure of chimeric carbonic anhydrase VI with 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
Summary for 6QL3
Entry DOI | 10.2210/pdb6ql3/pdb |
Related | 6QL1 6QL2 |
Descriptor | Carbonic anhydrase 2, ZINC ION, 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, ... (9 entities in total) |
Functional Keywords | drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 30654.83 |
Authors | Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2019-01-31, release date: 2019-09-25, Last modification date: 2024-01-24) |
Primary citation | Kazokaite, J.,Kairys, V.,Smirnoviene, J.,Smirnov, A.,Manakova, E.,Tolvanen, M.,Parkkila, S.,Matulis, D. Engineered Carbonic Anhydrase VI-Mimic Enzyme Switched the Structure and Affinities of Inhibitors. Sci Rep, 9:12710-12710, 2019 Cited by PubMed: 31481705DOI: 10.1038/s41598-019-49094-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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