6QGF
Galectin-3C in complex with a pair of enantiomeric ligands: R enantiomer
Summary for 6QGF
Entry DOI | 10.2210/pdb6qgf/pdb |
Descriptor | Galectin-3, (2~{S},3~{R},4~{S},5~{R},6~{R})-4-[4-(3-fluorophenyl)-1,2,3-triazol-1-yl]-2-[(2~{R})-3-[4-(3-fluorophenyl)-1,2,3-triazol-1-yl]-2-oxidanyl-propyl]sulfanyl-6-(hydroxymethyl)oxane-3,5-diol (3 entities in total) |
Functional Keywords | cell signalling drug design conformational entropy, sugar binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 16261.62 |
Authors | Manzoni, F.,Verteramo, M.L.,Oksanen, E.,Nilsson, U.J.,Logan, D.T. (deposition date: 2019-01-11, release date: 2019-01-23, Last modification date: 2024-01-24) |
Primary citation | Verteramo, M.L.,Stenstrom, O.,Ignjatovic, M.M.,Caldararu, O.,Olsson, M.A.,Manzoni, F.,Leffler, H.,Oksanen, E.,Logan, D.T.,Nilsson, U.J.,Ryde, U.,Akke, M. Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding. J. Am. Chem. Soc., 141:2012-2026, 2019 Cited by PubMed: 30618244DOI: 10.1021/jacs.8b11099 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.34 Å) |
Structure validation
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