6QFM
Structure of human Mcl-1 in complex with PUMA BH3 peptide
Summary for 6QFM
Entry DOI | 10.2210/pdb6qfm/pdb |
Related | 6qfi |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-binding component 3, ZINC ION, ... (5 entities in total) |
Functional Keywords | apoptosis, mcl1, bcl2, puma |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 21403.44 |
Authors | Dokurno, P.,Murray, J.,Davidson, J.,Chen, I.,Davis, B.,Graham, C.J.,Harris, R.,Jordan, A.M.,Matassova, N.,Pedder, C.,Ray, S.,Roughley, S.,Smith, J.,Walmsley, C.,Wang, Y.,Whitehead, N.,Williamson, D.S.,Casara, P.,Le Diguarher, T.,Hickman, J.,Stark, J.,Kotschy, A.,Geneste, O.,Hubbard, R.E. (deposition date: 2019-01-10, release date: 2019-06-12, Last modification date: 2024-01-24) |
Primary citation | Murray, J.B.,Davidson, J.,Chen, I.,Davis, B.,Dokurno, P.,Graham, C.J.,Harris, R.,Jordan, A.,Matassova, N.,Pedder, C.,Ray, S.,Roughley, S.D.,Smith, J.,Walmsley, C.,Wang, Y.,Whitehead, N.,Williamson, D.S.,Casara, P.,Le Diguarher, T.,Hickman, J.,Stark, J.,Kotschy, A.,Geneste, O.,Hubbard, R.E. Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1. Acs Omega, 4:8892-8906, 2019 Cited by PubMed: 31459977DOI: 10.1021/acsomega.9b00611 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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