6QEJ

CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR Thiophene-2-sulfonic acid (4-fluoro-benzyl)-(4H-[1,2,4]triazol-3-ylmethyl)-amide

Summary for 6QEJ

Entry DOI	10.2210/pdb6qej/pdb
Descriptor	Methionine aminopeptidase 2, 1,2-ETHANEDIOL, ~{N}-[(4-fluorophenyl)methyl]-~{N}-(1~{H}-1,2,4-triazol-5-ylmethyl)thiophene-2-sulfonamide, ... (6 entities in total)
Functional Keywords	hydrolase, peptidase, metal ion binding, proteolysis, hydrolase-hydrolase inhibitor complex
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	43068.68
Authors	Musil, D.,Heinrich, T.,Lehmann, M. (deposition date: 2019-01-07, release date: 2019-05-01, Last modification date: 2019-06-05)
Primary citation	Heinrich, T.,Seenisamy, J.,Blume, B.,Bomke, J.,Calderini, M.,Eckert, U.,Friese-Hamim, M.,Kohl, R.,Lehmann, M.,Leuthner, B.,Musil, D.,Rohdich, F.,Zenke, F.T. Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors. J.Med.Chem., 62:5025-5039, 2019 Cited by PubMed: 30939017 DOI: 10.1021/acs.jmedchem.9b00041 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation