6QEJ

CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR Thiophene-2-sulfonic acid (4-fluoro-benzyl)-(4H-[1,2,4]triazol-3-ylmethyl)-amide

6QEJ の概要

• エントリーDOI: 10.2210/pdb6qej/pdb
• 分子名称: Methionine aminopeptidase 2, 1,2-ETHANEDIOL, ~{N}-[(4-fluorophenyl)methyl]-~{N}-(1~{H}-1,2,4-triazol-5-ylmethyl)thiophene-2-sulfonamide, ... (6 entities in total)
• 機能のキーワード: hydrolase, peptidase, metal ion binding, proteolysis, hydrolase-hydrolase inhibitor complex
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43068.68

構造登録者

Musil, D.,Heinrich, T.,Lehmann, M. (登録日: 2019-01-07, 公開日: 2019-05-01, 最終更新日: 2019-06-05)

• 主引用文献: Heinrich, T.,Seenisamy, J.,Blume, B.,Bomke, J.,Calderini, M.,Eckert, U.,Friese-Hamim, M.,Kohl, R.,Lehmann, M.,Leuthner, B.,Musil, D.,Rohdich, F.,Zenke, F.T.; Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors.; J.Med.Chem., 62:5025-5039, 2019; PubMed: 30939017; DOI: 10.1021/acs.jmedchem.9b00041

実験手法

X-RAY DIFFRACTION (1.62 Å)