6QEI

CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR 5,6-Difluoro-3-(2-isopropoxy-4-piperazin-1-yl-phenyl)-1H-indole-2-carboxylic acid amide

Summary for 6QEI

Entry DOI	10.2210/pdb6qei/pdb
Descriptor	Methionine aminopeptidase 2, 1,2-ETHANEDIOL, GLYCEROL, ... (7 entities in total)
Functional Keywords	hydrolase, peptidase, metal ion binding, proteolysis, hydrolase-hydrolase inhibitor complex
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	43288.89
Authors	Musil, D.,Heinrich, T.,Lehmann, M. (deposition date: 2019-01-07, release date: 2019-05-01, Last modification date: 2024-05-15)
Primary citation	Heinrich, T.,Seenisamy, J.,Blume, B.,Bomke, J.,Calderini, M.,Eckert, U.,Friese-Hamim, M.,Kohl, R.,Lehmann, M.,Leuthner, B.,Musil, D.,Rohdich, F.,Zenke, F.T. Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors. J.Med.Chem., 62:5025-5039, 2019 Cited by PubMed: 30939017 DOI: 10.1021/acs.jmedchem.9b00041 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation