6QBU
Crystal structure of Porcine Pancreatic Elastase (PPE) in complex with the 3-Oxo-beta-Sultam inhibitor LMC188
Summary for 6QBU
Entry DOI | 10.2210/pdb6qbu/pdb |
Descriptor | Chymotrypsin-like elastase family member 1, ~{N}-[[1-[(4-chlorophenyl)methyl]-1,2,3-triazol-4-yl]methyl]-2-hydrosulfonyl-2-methyl-propanamide, PHOSPHATE ION, ... (6 entities in total) |
Functional Keywords | serine hydrolases, pancreatic porcine elastase, inhibitor, 3-oxo-beta-sultams, sulfonylation, hydrolase |
Biological source | Sus scrofa (Pig) |
Total number of polymer chains | 1 |
Total formula weight | 26616.95 |
Authors | Brito, J.A.,Almeida, V.T.,Carvalho, L.M.,Moreira, R.,Archer, M. (deposition date: 2018-12-21, release date: 2020-04-08, Last modification date: 2024-01-24) |
Primary citation | Carvalho, L.A.R.,Almeida, V.T.,Brito, J.A.,Lum, K.M.,Oliveira, T.F.,Guedes, R.C.,Goncalves, L.M.,Lucas, S.D.,Cravatt, B.F.,Archer, M.,Moreira, R. 3-Oxo-beta-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling. Acs Chem.Biol., 15:878-883, 2020 Cited by PubMed: 32176480DOI: 10.1021/acschembio.0c00090 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.38 Å) |
Structure validation
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