6QAU

Crystal structure of ULK2 in complexed with MRT67307

Summary for 6QAU

• Entry DOI: 10.2210/pdb6qau/pdb
• Descriptor: Serine/threonine-protein kinase ULK2, N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: ulk2, autophagy, kinase, inhibitor complex, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 97383.13

Authors

Chaikuad, A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium,Structural Genomics Consortium (SGC) (deposition date: 2018-12-19, release date: 2019-02-27, Last modification date: 2024-01-24)

• Primary citation: Chaikuad, A.,Koschade, S.E.,Stolz, A.,Zivkovic, K.,Pohl, C.,Shaid, S.,Ren, H.,Lambert, L.J.,Cosford, N.D.P.,Brandts, C.H.,Knapp, S.; Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).; Biochem.J., 476:875-887, 2019; PubMed: 30782972; DOI: 10.1042/BCJ20190038

Experimental method

X-RAY DIFFRACTION (2.48 Å)