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6QAF

Crystal structure of human Arginase-1 at pH 9.0 in complex with CB-1158/INCB001158

Summary for 6QAF
Entry DOI10.2210/pdb6qaf/pdb
Related6Q92 6Q9P
DescriptorArginase-1, MANGANESE (II) ION, [(~{E})-3-[(3~{S},4~{R})-4-azanyl-1-[(2~{S})-2-azanylpropanoyl]-4-carboxy-pyrrolidin-3-yl]prop-1-enyl]-tris(oxidanyl)boranium, ... (5 entities in total)
Functional Keywordsarignase inhibitor, borate, manganese cluster, ph-dependent, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight74772.41
Authors
Grobben, Y.,Uitdehaag, J.C.M.,Tabak, W.W.A.,Zaman, G.J.R. (deposition date: 2018-12-19, release date: 2019-12-11, Last modification date: 2024-01-24)
Primary citationGrobben, Y.,Uitdehaag, J.C.M.,Willemsen-Seegers, N.,Tabak, W.W.A.,de Man, J.,Buijsman, R.C.,Zaman, G.J.R.
Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158.
J Struct Biol X, 4:100014-100014, 2020
Cited by
PubMed: 32647818
DOI: 10.1016/j.yjsbx.2019.100014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.61 Å)
Structure validation

223166

数据于2024-07-31公开中

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